Research on CBD (Cannabidiol)

Cancer-Related Research with Cannabidiol (CBD)

That’s Natural! is excited about the discoveries being made about cannabidiol (CBD) and the inherent endocannabinoid system that exists in each of our bodies.  We hope you will do research for yourself, here are some links to investigate for yourself, concerning cancer-related issues.

1- Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium

2- Cannabidiol as potential anticancer drug

3- Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1

4- Cannabidiol inhibits angiogenesis by multiple mechanisms

5- The inhibitory effects of cannabidiol on systemic malignant tumors

 

Prostate & Colon Cancer

1- Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer

2- Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent

3- In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines

4- Towards the use of non-psychoactive cannabinoids for prostate cancer

5- Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

Brain

1- Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines

2- Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival

3- Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas

4- Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism

5- Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target

6- Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme

7- Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

8- Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents

Lung Cancer

1- Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C

2- COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells

3- Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells

Leukemia

1- Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression

2- Cannabidiol-Induced Apoptosis in Human Leukemia Cells

Bladder Cancer

1- TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer

Endocrine

1- A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells

2- Endocannabinoids in endocrine and related tumours

Skin Cancer

1- Anticancer activity of anandamide in human cutaneous melanoma cells

Breast Cancer

1- Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

2- Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

3- Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

4- Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy

5- Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration

Cancer-Related Pain

1- Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain

2- Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial

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