The Impact of CBD (Cannabidiol) on Arthritis

Arthritis is one of the main issues that people use cannabidiol (CBD), and it is also one of the most researched areas regarding CBD. Research on CBD for inflammation and arthritis.  See more from That's Natural full spectrum CBD-rich hemp oil at and - find us in the Aspen Valley at Life Force Market in Basalt, Colorado

Arthritis is one of the main issues that people use cannabidiol (CBD), and it is also one of the most researched areas regarding CBD. Below are summaries of two studies regarding CBD and arthritis.

This study from the National Institutes of Health (NIH) examines the impact of CBD on the paw of rats. The point of the study was to examine the anti-inflammatory and anti-hyperalgesic effects of CBD, given once a day for three days, after the onset of acute inflammation. Prostoglandin E2 (PGE2) was assayed in the plasma, and cyclooxygenase (COX) activity, production of nitric oxide, and other oxygen-derived free radicals in the inflamed paw tissues.

All these markers were increased following carrageenan. Cannabidiol had a time and dose-dependent anti-hyperalgesic effect after just a single injection. Edema peaked at three hours and lasted 72 hours. The study says:

“a single dose of cannabidiol reduced edema in a dose-dependent fashion and subsequent daily doses caused further time- and dose-related reductions. There were decreases in PGE2 plasma levels, tissue COX activity, production of oxygen-derived free radicals, and NO after three doses of cannabidiol. The effect on NO seemed to depend on a lower expression of the endothelial isoform of NO synthase. In conclusion, oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia.”

A second study examines the impact of transdermal/topical CBD on arthritis. Again, plasma was measured after administering as little as 0.6mg/day. “Transdermal CBD gel significantly reduced joint swelling, limb posture scores as a rating of spontaneous pain, immune cell infiltration and thickening of the synovial membrane in a dose-dependent manner” said the study. Finally, the conclusion of the study was, “These data indicate that topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.”


That’s Natural products are considered to be full spectrum meaning they contain cannabinoids and terpenes from the whole plant. Every mammal has an endocannabinoid system,  which is fueled by these cannabinoids and terpenes.   The combination of these compounds help to provide what is known as the entourage effect. Here you can listen to Dr. David Allen explain how the endocannabinoid system contributes to how our immune system and nervous system function.  By providing pure, potent, and trusted products, That’s Natural continues to strive to meet our customer’s needs – something we have been doing for twelve years! With 100% traceability of where our hemp comes from, you can be confident in what you are putting on, or in, your body. For more questions regarding our CBD products, please visit our Questions and Answers page.


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