A lot of people are curious as to how CBD can impact their bones. It turns out, that anecdotal research shows that it may impact them dramatically – at least in mice. According to this study, the endocannabinoid system, has been implicated in the regulation of bone metabolism.
Cannabinoids interact with type 1 (CBD1 and CB2) cannabinoid receptors and the GPR55 receptor to regulate cellular function through various signaling pathways. The study points out that endocannabinoids are actually produced in bone, but it is unknown how the mechanisms regulate their production work.
“Mice with CB(1) deficiency have high peak bone mass as a result of an osteoclast defect but develop age-related osteoporosis as a result of impaired bone formation and accumulation of bone marrow fat. Mice with CB(2) deficiency have relatively normal peak bone mass but develop age-related osteoporosis as a result of increased bone turnover with uncoupling of bone resorption from bone formation. Mice with GPR55 deficiency have increased bone mass as a result of a defect in the resorptive activity of osteoclasts, but bone formation is unaffected.”
The study goes on to say that cannabinoids are also produced within synovial tissues (a specialized connective tissue that lines the inner surface of capsules of synovial joints and tendon sheath. It makes direct contact with the synovial fluid lubricant, which it is primarily responsible for maintaining.) Preclinical studies show that cannabinoid receptor ligands are effective in treatment of inflammatory arthritis. “These data indicate that cannabinoid receptors and the enzymes responsible for ligand synthesis and breakdown play important roles in bone remodeling and in the pathogenesis of joint disease.”
That’s Natural products are considered to be full spectrum meaning they contain cannabinoids and terpenes from the whole plant. Every mammal has an endocannabinoid system, which is fueled by these cannabinoids and terpenes. The combination of these compounds help to provide what is known as the entourage effect. Here you can listen to Dr. David Allen explain how the endocannabinoid system contributes to how our immune system and nervous system function. By providing pure, potent, and trusted products, That’s Natural continues to strive to meet our customer’s needs – something we have been doing for twelve years! With 100% traceability of where our hemp comes from, you can be confident in what you are putting on, or in, your body. For more questions regarding our CBD products, please visit our Questions and Answers page.
*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.