Research on CBD (Cannabidiol)

The Deficiency of Cannabinoids Could Explain Several Health Issues

Have you ever heard of Endocannabinoid Deficiency?  This may actually contribute to a variety of #health issues.  Supplementing with high-quality full-spectrum cannabinoids like That’s Natural CBD-rich hemp oil – may benefit your wellness regimen!  See more at and @cbdhempoil – and soon find us in the #Aspen Valley at our Life Force Market @thatsnatural  #ThatsNatural  #anxiety #depression #PTSD #inflammation #immunity #immunebooster #immunesupport #motivation #essentialoils #skin #skincare

Before understanding why a deficiency of cannabinoids may be the reason for health issues such as migraines, fibromyalgia, irritable bowel syndrome (IBS), and other treatment-resistant conditions, we have to understand what the endocannabinoid system is. In short, Dr. Raphael Mechoulam discovered this system in 1992, and it is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems. It consists of neuromodulatory lipids and their receptors.

A study by the National Institutes of Health has found how endocannabinoid deficiency has impacted several disorders. Migraines have been found to have numerous correlations with endocannabinoid function. “Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects. AEA is tonically active in the periaqueductal gray matter, a migraine generator.”

The study concluded by saying:

“Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging.”

So, how do we prevent our body from entering endocannabinoid deficiency? One of the easiest ways to “feed” our body the substances that it is lacking. There are dozens of cannabinoids, but the main ones are Cannabidiol (CBD), Cannabidiol Acid (CBDA), Cannabinol (CBN), Cannabigerol (CBG), and Cannabichromene (CBC) – all of which are contained in That’s Natural’s products. These cannabinoids bind to our cannabinoid receptors, CB1 and CB2, to activate our endocannabinoid system. By consuming products containing these cannabinoids, it is believed to diminish a person’s likelihood of developing an endocannabinoid deficiency.


Each person has an endocannabinoid system, which is fueled by a variety of cannabinoids and terpenes. Because our products have these cannabinoids and terpenes, they are known to be full spectrum products. These full spectrum products help provide an entourage effect. That’s Natural has been in business for over 10 years and believes in providing the most pure, potent, and trusted products possible. We even provide 100% traceability of where our hemp comes from. For more questions regarding our CBD products, please visit our Questions and Answers page.

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