Research on CBD (Cannabidiol)

One Reason CBD Helps Decrease Anxiety

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CBD has often been shown to decrease anxiety, but it hasn’t been known why, until a study in 2004 from PubMed. The goal of this study was to develop a better understanding of why CBD had been shown to have anxiolytic effects. In order to do this, neuroimaging was used to show regional cerebral blood flow in ten healthy male volunteers. The volunteers were split into two groups (five men each) and studied on two occasions. On one occasion, they were given CBD and on the other, they were given a placebo.

In this double blind study, images were acquired from the neuroimaging ninety minutes after the CBD (or placebo) was given. The findings of this study were as follows:

“CBD significantly decreased subjective anxiety and increased mental sedation, while placebo did not induce significant changes. Assessment of brain regions where anxiolytic effects of CBD were predicted a priori revealed two voxel clusters of significantly decreased ECD uptake in the CBD relative to the placebo condition (p<0.001, uncorrected for multiple comparisons). These included a medial temporal cluster encompassing the left amygdala-hippocampal complex, extending into the hypothalamus, and a second cluster in the left posterior cingulate gyrus. There was also a cluster of greater activity with CBD than placebo in the left parahippocampal gyrus (p<0.001).”

These results suggest that CBD has anxiolytic properties, and that it because of an action in the limbic and Para limbic brain areas.

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